A fast and transient engagement to the IS in the DG-based signalosome induced by Ag recognition has also been described for PKCα, leading to the activation of Ras/ERK pathway and shedding of CD62L (L-selectin) [259], favoring the progenitor differentiation into effector memory T cells (TEM), and their migration toward peripheral tissues [260], including tumor sites. The gene discussed is PRKCA; the disease is neoplasm.