CD274 and cancer: Of note, a valuable study was conducted by Abdelatty et al. [321] by employing the single-cell gene set enrichment analysis and the ESTIMATE methods to analyze the tumor-infiltrating lymphocytes (TILs) and the immune components found within 28 cancer types, and correlating response to immunotherapies with PKC levels, based on human leukocytic antigen gene enrichment scores and PD-L1 expression.