Indeed, CD4+ T cells from PKCδ defective mice also display distinctive defects, including impaired ERK signaling, reduced DNA methyltransferase 1 (DNMT1) expression and the increased methylation of genes implicated in the amplified immune response scenario representative of lupus [274], supporting a critical role for PKCδ as an immune gatekeeper, as suggested by Salzer et al. [273]. Here, DNMT1 is linked to systemic lupus erythematosus.