TRIM32 and autosomal recessive limb-girdle muscular dystrophy type 2H: Protein extracts of quadriceps muscles excised from TRIM32-knockout mice that had been exposed to atrophy-inducing dexamethasone revealed defects in autophagic flux, as indicated by a reduced level of LC3-II (an autophagy marker protein) [63], suggesting that impaired autophagy during skeletal muscle atrophy may contribute to LGMD2H pathogenesis.