Similarly, impaired autophagy has been identified in TRIM32-knockdown C2.7 cells expressing LGMD2H-causing TRIM32 R394H or D487N mutants after dexamethasone treatment to induce atrophy and in transdifferentiated myoblasts from the fibroblasts of an LGMD2H patient harboring the TRIM32 R613X mutation [63,114]. This evidence concerns the gene TRIM32 and autosomal recessive limb-girdle muscular dystrophy type 2H.