Previous studies on TRIM32 and LGMD2H-causing TRIM32 genetic variants in skeletal muscle have focused mainly on atrophy and atrophy-related protein-protein interactions, especially interactions between TRIM32 and substrates of TRIM32 functioning as an E3 ubiquitin ligase. The gene discussed is TRIM32; the disease is autosomal recessive limb-girdle muscular dystrophy type 2H.