A protective role of Hoxa5 was reported in the studies of Cao W et al., which demonstrated that Hoxa5 alleviates obesity-induced chronic inflammation by reducing pro-inflammatory cascades, including ER stress- and TNC/TRL4/NF-κB (Tenascin-C/Toll-Like Receptor 4/Nuclear Factor Kappa B) inflammatory pathways and, importantly, by promoting anti-inflammatory M2 macrophage polarization in mouse AT [34,70]. Here, TNC is linked to obesity due to melanocortin 4 receptor deficiency.