In line with the current evidence that DNA methylation alterations in genes regulating AT function may be one of the crucial mechanisms linking obesity to its clinical complications, such as IR and T2D [50,85,86], the HOXA5 gene has been shown to undergo dynamic changes in DNA methylation in metabolic diseases related to AT dysfunction. The gene discussed is HOXA5; the disease is obesity due to melanocortin 4 receptor deficiency.