Examples include beta-secretase 1 (BACE1)-AS, whose expression is increased upon amyloid-beta 1–42 production in Alzheimer’s disease [7], and nuclear-enriched abundant transcript 1 (NEAT1), that is upregulated in different models of Parkinson’s disease interacting with the PTEN-induced kinase 1 (PINK1) protein [8]; Finally, several lncRNAs, such as DGCR5 and HAR1, are dysregulated in Huntington’s disease [9]. The gene discussed is BACE1; the disease is early-onset autosomal dominant Alzheimer disease.