The investigators showed that, along with an increased frequency of morphologically polarized cells, CLL cells stimulated with type B and C CpG showed higher migratory activity in vitro and, when injected intravenously, showed a higher frequency of homing to the bone marrow of NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice. This evidence concerns the gene CTSG and B-cell chronic lymphocytic leukemia.