Of the 587 CLL patients analyzed, 3.9% were mutated, of which 19 were MYD88 (1 patient also had an IRAK1 co-mutation), 2 were TLR2 (1 patient had a TLR6 co-mutation), 1 was IRAK1, and 1 was TLR5. This evidence concerns the gene TLR5 and B-cell chronic lymphocytic leukemia.