When evaluating the analyzed subpopulations of lymphocytes positive for the tested TLRs between CVID and CLL patients, the following have the greatest potential: CD4+TLR2+, CD8+TLR2+, CD19+TLR2+, as well as CD8+TLR4+ and CD4+TLR9+ (Table 8, Figure 13A,B,F). This evidence concerns the gene TLR4 and B-cell chronic lymphocytic leukemia.