When evaluating the analyzed subpopulations of lymphocytes positive for the tested TLRs between CVID and CLL patients, the following have the greatest potential: CD4+TLR2+, CD8+TLR2+, CD19+TLR2+, as well as CD8+TLR4+ and CD4+TLR9+ (Table 8, Figure 13A,B,F). The gene discussed is TLR4; the disease is common variable immunodeficiency.