CHRNA4 and autosomal dominant nocturnal frontal lobe epilepsy: Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), now renamed (AD)SHE, or (Autosomal dominant) sleep-related hypermotor epilepsy [222], was first linked to a missense mutation on CHRNA4 (α4S248F) [26,206,223].