IGKV2D-24 and Alzheimer disease: α7 and α4β2 nAChRs have been associated with the pathogenesis of a range of neurological disorders, e.g., Alzheimer disease (AD) [23], schizophrenia spectrum disorders [24], Parkinson disease (PD) [25], nocturnal frontal lobe epilepsy [26], autism spectrum disorder [27], attention deficit hyperactivity disorder [28], and depression [29], to name some of the most relevant ones.