Mechanistically, during mesothelioma development, when mesothelial cells experience asbestos, fibers secrete several macrophage-attractant factors, including interleukin (IL)-8, IL-6, C-C motif chemokine ligand 2 (CCL2 or also called monocyte chemoattractant protein-1, MCP-1), granulocyte colony-stimulating factor (G-CSF), granulocyte/macrophage colony-stimulating factor (GM-CFS), and macrophage inflammatory protein-1 (MIP)-1alpha, which start the inflammatory cascade, and, in turn, recruit other monocytes at the tumor site [24,25,26]. This evidence concerns the gene CSF3 and neoplasm.