In response to high ROS levels and DNA damage, mesothelioma cells overexpress nuclear factor erythroid 2-related factor 2 (Nrf2), redox effector factor 1 (Ref-1), and forkhead box protein M1 (FOXM1) involved in the antioxidant pathways to reduce oxidative stress. This evidence concerns the gene FOXM1 and mesothelioma.