The GR-mediated upregulation of LEDGF/p75 in enzalutamide-resistant cells needs to be further evaluated in future mechanistic and clinical studies with patient samples aimed at determining the possible contribution of LEDGF/p75 and its interacting partners regulated by GR, such as the MYC-binding protein JPO2, to PCa resistance to enzalutamide and other ARSI. Here, MYC is linked to posterior cortical atrophy.