In a recent study, we demonstrated that LEDGF/p75 interacts with several members of its IBD protein interactome (e.g., Menin, MLL, JPO2, and PogZ) in DTX-resistant PCa cells and that some of these interactions are critical for maintaining cell survival, clonogenicity, and tumorsphere formation [38]. The gene discussed is POGZ; the disease is posterior cortical atrophy.