NR3C1 and posterior cortical atrophy: Although the mechanisms underlying GR-mediated PCa chemoresistance still remain to be fully elucidated, there is evidence for the downregulation of the anti-apoptotic genes Bcl-xL and Bcl-2 upon GR antagonism, as well as for the GR-mediated upregulation of mono amine oxidase-A (MAO-A), a mitochondrial oxidoreductase, in patients treated with DTX [20,23].