Silencing of Cables inhibits neurite growth in primary cortical neurons, whereas increased expression of active c-Abl results in neurite elongation [82], and inhibition of c-Abl/CABLES/p-CDK5 signaling by Dexibuprofen prevents impairment of spatial learning and memory loss in a transgenic AD mouse model [75]. The gene discussed is CDK5; the disease is Alzheimer disease.