In AD animal models, c-Abl interacts directly with the cytosolic domain of Alzheimer’s amyloid precursor protein (APP), and Tyr682 phosphorylation in the cytoplasmic tail of APP is essential for APP-BACE1 interaction and promotion of amyloidogenic processing of APP to Aβ-oligomers and the carboxy-terminal fragment βCTF [43,73]. This evidence concerns the gene BACE1 and Alzheimer disease.