In Drosophyla neuronal cells, active c-Abl appears to be required for Cdk5 binding, activation, and translocation, but unlike in humans, is not required for the conversion of p35 to p25, suggesting that Cdk5 activation and translocation are independent of p25 in the Drosophila model of AD [99]. The gene discussed is CDK5; the disease is Alzheimer disease.