c-Abl also mediates neuronal cell death via the interaction of HDAC3 and c-Fos in mouse models of Huntington’s disease, where c-Fos expression is selectively reduced in the striatum and its forced expression has been shown to protect against the neurotoxic effects of activated c-Abl and HDAC3 [101]. The gene discussed is ABL1; the disease is juvenile Huntington disease.