Since the ATPase activity of RECQ5 plays a crucial role in anti-RAD51 recombinase activity [23], further biochemical analyses are necessary to determine the potential impact of the breast cancer-associated RECQ5 variants within the SFII and RQC domains on the ATPase activity of RECQ5 and its ability to disassemble the RAD51 filament on DNA. Here, RAD51 is linked to breast cancer.