Since the ATPase activity of RECQ5 plays a crucial role in anti-RAD51 recombinase activity [23], further biochemical analyses are necessary to determine the potential impact of the breast cancer-associated RECQ5 variants within the SFII and RQC domains on the ATPase activity of RECQ5 and its ability to disassemble the RAD51 filament on DNA. The gene discussed is RECQL5; the disease is breast cancer.