Therefore, the aim of the current study was to (i) confirm the induction of PCOS in rats by measuring plasma levels of steroids: T and estradiol (E2) and metabolic parameters: glucose, triglycerides, total cholesterol, and high-density lipoprotein (HDL) levels as well as the characterization of ovarian and uterus histology; (ii) describe plasma levels of RARRES2 and ADIPOQ; and (iii) mRNA and protein expression of RARRES2 and its receptors, CCRL2, CMKLR1, GPR1, as well as ADIPOQ, and its receptors ADIPOR1 and ADIPOR2 in the uterine of control and PCOS-induced rats. Here, RARRES2 is linked to polycystic ovary syndrome.