OPA1 and ocular melanoma: As expected, Myls22 and TPEN, but not SfA, attenuated Ca2+-induced cleavage of L-OPA1 in the presence of OM as evidenced by high levels of L-OPA1 (approximately 64% and 72% for Myls22 and TPEN, respectively) and low levels of S-OPA1 in these groups compared to the Ca2+-treated group used as a control (untreated with Myls22 and TPEN) (Figure 5C).