Carneiro et al. observed that in mice lacking the gp91phox subunit and inoculated intradermally in the ear with Leshmania amazonensis, the pathology was exacerbated after infection, there was an increase in the number of neutrophils in the infection area, the number of parasites was not affected, and finally, there was an increase in tissue necrosis [26]. The gene discussed is CYBB; the disease is infection.