In contrast, an analysis by de Mello et al. found that the expression of genes (i.e., IKBKB, CCL5, and ICAM-1) involved in NF-κB activation was significantly reduced after weight loss (~4.5% BW and 1.5% FM) in patients with metabolic syndrome undergoing dietary therapy [32]. The gene discussed is ICAM1; the disease is metabolic syndrome.