CD4 and vitamin D deficiency: At HAART initiation, virologic failure (VL > 1000 copies/mL), immunosuppression (CD4 count < 200 cells/mm3), inflammation (hsCRP > 3 mg/dL), and vitamin-D deficiency (<20 ng/dL) were 10%, 9%, 52%, and 42%, and at 12 years of HAART experience, all significantly increased to 47%, 38%, 78%, and 70%, respectively (Figure 4).