Moreover, it was also theorised that uncontrolled hyperglycemia may cause aberrant glycosylation of ACE2 in lungs, nasal airways, tongue, and oropharynx, thus increasing SARS-CoV-2 viral binding sites and leading to a higher trend of SARS-CoV-2 infections and more severe forms of COVID-19 [28]. This evidence concerns the gene ACE2 and Hyperglycemia.