Potential mechanisms by which mRNA COVID-19 vaccination could produce prions and trigger neurodegenerative processes include: RNA binding proteins like TAR DNA binding protein (TDP-43) and Fused in Sarcoma (FUS) can be activated to form disease-causing prions; TDP-43 dimers bind UG-rich RNA or TG-rich DNA and are resistant to degradation [203] and binding to these RNA sequences when the proteins are cytoplasmic may cause misfolding leading to prion formation [204]. The gene discussed is TARDBP; the disease is COVID-19.