Furthermore, autoantibodies in the globular C-terminal domain can cause Creutzfeldt Jakob Disease (CJD) [218], miR-146a is altered in association with COVID-19 [222] and associated with both viral infection and prion diseases in the brain, and S1 has been shown to induce senescence in transfected cells. Here, PSMD1 is linked to Creutzfeldt Jacob disease.