Considering that the combined inhibition of IDO-1 and CXCR-2 (K14E7E2 + CT) exhibited a more significant effect in reducing cervical tumor areas compared to single-drug treatment in mice that developed CIN-III/CC (K14E7E2), we decided to utilize this regimen for our subsequent experiments. The gene discussed is IDO1; the disease is uterine cervix carcinoma in situ.