In a series of 88 tumors, the percentage of tumors with downregulation of LATS1 and LATS2 due to promoter hypermethylation increased significantly from 48%/52% in grade 2 astrocytomas to 65%/70% in grade 3 astrocytomas and to 73%/82% in grade 4 glioblastomas [51]. This evidence concerns the gene LATS2 and astrocytoma (excluding glioblastoma).