Indeed, the competitive relationship between the different types of ncRNAs has been confirmed, as had the direct influence of individual ncRNAs on signaling pathways such as an EGFR-independent activation of epidermal growth factor (EGF) by a circular RNA called “circ-E-Cad” overexpressed in glioblastomas [159]. The gene discussed is CDH1; the disease is glioblastoma.