Involvement of the inactivated hippo pathway due to decreased expression of MST1/2 or LATS1/2 or even due to the overactivation of YAP1 and TAZ has been confirmed in various tumor types, such as colorectal and prostate cancer and even in astrocytomas and glioblastomas [50]. The gene discussed is LATS1; the disease is astrocytoma (excluding glioblastoma).