Other possible consequences of the activity of circRNAs are the downregulation of apoptotic effectors such as caspase 3 [137] or the upregulation of tumor suppressors such as the presynaptic adhesion molecule neurexin 3 (NRXN3), which inhibits glioma growth in vivo [142] (Figure 2). The gene discussed is NRXN3; the disease is glioma.