Although mutations cannot be detected directly by methylome analysis, the indirect detection of important changes such as 1p/19q codeletions in oligodendrogliomas, IDH mutations, or even methylation of O6-methylguanine-DNA-methyltransferase (MGMT) can be performed due to the resulting changes in methylation patterns [31,99]. This evidence concerns the gene IDH2 and oligodendroglioma.