As the hippo signaling pathway can be modulated by several other signaling pathways, such as MAPK, WNT, NOTCH, and by different tyrosine kinase receptors (RTKs), the hippo signaling pathway can be considered a prime example of the distinct interconnectivity of all molecular signaling pathways in the mammalian cell, including glioma cells [49,50]. Here, NTRK1 is linked to central nervous system cancer.