EGFR and central nervous system cancer: Over 50 different RTKs have been identified in humans; the major receptors overexpressed in many gliomas are the epidermal growth factor receptor (EGFR), the platelet-derived growth factor receptor (PDGFR), the insulin-like growth factor receptor 1 (IGF1R), the fibroblast growth factor receptor (FGFR), and the vascular endothelial-growth factor receptor (VEGFR).