An inverse correlation between GPX4 expression and accumulation of 8-hydroxy-2′-deoxyguanosine, the end-product of oxidation, has been observed in diffuse large B-cell lymphoma (DLBCL) [43], whereas GPX4 expression is upregulated, and oxidative stress is reduced in colon cancer [44]. Here, GPX4 is linked to malignant colon neoplasm.