An inverse correlation between GPX4 expression and accumulation of 8-hydroxy-2′-deoxyguanosine, the end-product of oxidation, has been observed in diffuse large B-cell lymphoma (DLBCL) [43], whereas GPX4 expression is upregulated, and oxidative stress is reduced in colon cancer [44]. This evidence concerns the gene GPX4 and colonic neoplasm.