In addition, using Oncomine, a gene expression comparison database, 12 of the above 40 genes were selected based on the condition that they are related to transcription and have higher mRNA expression in HCC than in normal hepatocytes (FOXA1, FOXP1, MCRS1, MED1, PROX1, RUVBL1, SMARCA4, SP1, SPI1, TEAD4, YY1, and ZMYM3). This evidence concerns the gene SP1 and hepatocellular carcinoma.