It may also be worthwhile to investigate reducing free Ang2 levels in DMD as, in this context, it may shift the Ang1/Ang2 balance back towards an Ang1-favored ratio, which can promote Tie2 activation, maturation of the angiogenic cascade and establish a stabilized endothelium that can support functional perfusion and endogenous muscle repair. This evidence concerns the gene TEK and Duchenne muscular dystrophy.