In the current study, we assessed two sets of tumors for the exhaustion status of the infiltrated CD8, the first set included PAAD and HNSC which experienced a negative correlation between CDKN2A alterations and CD8 T cell infiltration, while the second set included BLCA and LUSC and did not experience the above-mentioned negative correlation. This evidence concerns the gene CDKN2A and bladder transitional cell carcinoma.