CDKN2A and neoplasm: The final assessment at this stage was the correlation between CDKN2A and tumor metastasis where six human tissues (colon, intestine, liver, lung, prostate, and skin) demonstrated a significant upregulation in CDKN2A levels in cancerous tissue versus normal one and this upregulation was consistent in metastatic tissue in comparison to normal and cancerous ones (Figure 1E).