In COVID-19, it is induced by a multimodal activation of NLRP3 inflammasome: hyperactivation of Ang II-AT1R axis secondary to ACE2 binding to S protein; direct interaction between SARS-CoV-2 nucleocapsid (N) protein and NLRP3 inflammasome; calcium leakage into the cytosol through ion channels formed by SARS-CoV-2 envelope (E); potassium efflux; and reactive oxygen species (ROS) production induced by SARS-CoV-2 [34,35,36,37,38,39]. The gene discussed is NLRP3; the disease is COVID-19.