Subsequent studies showed that NKX3-1, a prostate-specific tumor suppressor, plays an important role in iPSC initiation [12], and the NCoR/SMRT corepressor binds to the pluripotency locus and creates a barrier to initiation by the four Yamanaka factors (Oct4, Sox2, Klf4, and c-Myc), resulting in a significant increase in the efficiency and speed of initiation by suppressing NCoR/SMRT [13]. This evidence concerns the gene NCOR2 and neoplasm.