The expression of the calcium-sensing receptor (CaSR) in human colonic crypt epithelium is associated with cell differentiation, its absence is associated with undifferentiated and invasive colon cancer, and CaSR-deficient cells show an increased expression of the cancer stem cell markers CD133, CD44, Nanog, and epithelial mesenchymal transition molecules, the transcription factors N-cadherin, beta catenin, vimentin, fibronectin, Snail1, Snail2, Twist, FOXC2, and oncogenic miR21, miR135a, and miR135b [47]. The gene discussed is CASR; the disease is cancer.