PRKN and Parkinson disease: Because mitochondrial dysfunction resulting from alterations in genes related to mitophagy, such as LRRK2, DJ-1, PINK1, and PRKN, can lead to the production of ROS and aggregation of α-synuclein (major component of Lewy bodies, pathological hallmarks, and typically found in PD), these genes might be involved in promoting the neurodegeneration observed in PD [10].