Parkinson’s disease is characterized by the progressive loss of dopaminergic neurons in the substantia nigra of the central nervous system and by the accumulation of misfolded intracellular a-synuclein, leading to impaired muscle function, which causes symptoms such as bradykinesia, tremors, postural instability, and muscle rigidity, as well as non-motor symptoms such as depression, cognitive impairment, dementia, and anxiety [16,17,18,19]. This evidence concerns the gene SNCA and Parkinson disease.