NFKB1 and neoplasm: The shCtrl SK28 cells followed the expected growth kinetics, which continued to grow until the point where ethical considerations determined the termination of the mice; knockdown of NAC1 or treatment with BAY 11-7082 alone only showed a modest inhibitory effect on tumor growth; however, the depletion of NAC1 in combination with BAY 11-7082 elicited a strong inhibitory effect on tumor growth (Figure 4C), suggesting a synergistic antitumor action between the co-targeting of NAC1 and NF-κB.