NACC1 and melanoma: To verify this observation, we investigated the NAC1-IL-1β connection in two melanoma cell lines with different genetic backgrounds: the A2058 cell line was derived from genetically engineered mouse models (Ptenf/f) of melanoma (Figure 1B) and the SK28 cell line was established from patient-derived tumor samples and expressed mutant B-Raf (V600E) (Figure 1C).