These variants were found in inflammasome genes (NLRP1/3 and CASP1), genes mediating inflammasome inactivation via auto- and mitophagy (RIPK2 and MEFV), and genes involved in the response to infection with DNA viruses (POLR3A, DHX58, and IFIH1) and type-1 interferons (TYK2 and PTPRC) [38]. The gene discussed is CASP1; the disease is infection.