Dysregulation of the stress axis by IL-10 can lead to numerous inflammatory diseases such as neuropathic pain, Parkinson’s disease, Alzheimer’s disease, osteoarthritis, rheumatoid arthritis, psoriasis, systemic lupus erythematosus, type 1 diabetes, inflammatory bowel disease, and allergies Natural anti-inflammatory compound curcumin has the ability to increase IL-10 synthesis and expression while also enhancing its effects on a range of tissues. Here, IL10 is linked to osteoarthritis.