However, animals that received the B1 receptor antagonist and B1KO animals showed the lowest levels of creatinine (Figure 1A,D), urea (Figure 1B,E), and tubular injury score (Figure 1C,F), also evaluated by hematoxylin and eosin staining (Figure 1J–L), indicating the protective role of B1R in acute kidney injury. The gene discussed is BDKRB1; the disease is acute kidney injury.