In the secondary APS subgroup, aPT IgM or IgG isotypes registered non-significant correlations with non-criteria (aPS IgG and aPE IgG) and criteria aPLs (aCL IgG, aβ2GPI IgG, and aβ2GPI IgM). The gene discussed is CD40LG; the disease is autoimmune polyendocrinopathy.