The aim of this research was to evaluate the correlations between six non-criteria aPLs, namely the IgM and IgG isotypes of anti-phosphatidylethanolamine (aPE), anti-phosphatidylserine (aPS), and anti-prothrombin (aPT) antibodies, with the IgM and IgG isotypes of criteria aCL and aβ2GPI, in order to identify aPLs with different kinetics than criteria antibodies, which might be used as new serological tools for APS diagnosis. The gene discussed is F2; the disease is autoimmune polyendocrinopathy.