ACLY and autoimmune polyendocrinopathy: However, out of this extensive group, only lupus anticoagulant (LAC), IgG or IgM isotypes of anti-cardiolipin (aCL) antibodies, and IgG or IgM isotypes of anti-β2 glycoprotein I antibodies (aβ2GPI) are currently included in the APS classification criteria [1].