According to Volkov et al., aPT IgG positivity is associated with arterial thrombosis, and the presence of aCL IgG and aPS IgG or the isolated detection of anti-annexin-5 (aAN) IgG seems to be correlated with APS-specific pregnancy pathology, while aPT IgG, anti-phosphatidylglycerol (aPG) IgG, anti-phosphatidylinositol (aPI) IgG, and aAN IgG were connected to CNS manifestations of the APS [23]. This evidence concerns the gene ANXA5 and Arterial thrombosis.