The spatial synergism of IL-1β and IL-17 sheds light on their combined effect in disc degeneration, and allows us to consider their participation in reactive spondylitis and erosion of the vertebral bodies as the main promoters of bone remodeling in DDD by analogy with autoimmune rheumatic diseases (rheumatoid arthritis, psoriatic arthritis, etc.)[24,25]. The gene discussed is IL1B; the disease is intervertebral disk degenerative disorder.