In the DDD group, a coincidence of the spatial expression of IL-1β and IL-17 was found (in 21.62 ± 9.90% of immunopositive chondrocyte)–in the endothelium and in the perivascular zone, as well as in the vascular lumen (p < 0.01). The gene discussed is IL1B; the disease is Dowling-Degos disease 1.