Moreover, in the thoracic aortic segments of mice with CKD, adiponectin further augmented the vasorelaxation induced by acetylcholine at a concentration of 10−5 M at CKD + adiponectin group (CKD + adiponectin group: 18.6 ± 2.0% vs. CKD group: 11.5 ± 2.5%, * p < 0.05, as shown in Figure 2). Here, ADIPOQ is linked to chronic kidney disease.