Regarding mitochondrial dynamics, the LKB1-AMPK pathway is known to restore the function of damage-activating fusion processes but the upregulation of HIF-1α in the tumor mitochondria increases the activity of dynamin-related Protein 1 (DRP1) and unbalances mitochondrial dynamics toward fission by downregulating the expression of mitofusin-1 (MFN1) and optic atrophy 1 (OPA1) [32]. The gene discussed is DNM1L; the disease is neoplasm.