Also, treatment with BMP7 in an animal model of atherosclerosis resulted in the inhibition of monocyte infiltration, a decrease in pro-inflammatory cytokines and an increase in anti-inflammatory cytokines, and an increase in M2 macrophage populations [18], suggesting that the shift toward M2 differentiation could be one of the main contributions of BMP7 in inflammation. This evidence concerns the gene BMP7 and atherosclerosis.