Since protein overexpression was reported to potentially lead to unphysiological effects in transfected cells, the same research group later developed an independent and complementary xenograft-based model of ovarian cancer, in which the high RNASET2-expressing OVCAR3 ovarian cancer cell line was genetically engineered to completely knock-down endogenous RNASET2 expression with RNA interference [121]. Here, RNASET2 is linked to ovarian carcinoma.