Consequently, the primary aim of the present study was to evaluate whether analysis of calprotectin might be an economically beneficial complement to conventionally used biomarkers of infection, i.e., CRP, white blood cell count (WBC), and PCT, in a previously published cohort of unselected ICU patients [16], where the aim was to assess plasma calprotectin as an early marker of bacterial infections in critically ill patients in comparison with PCT, CRP, and WBC. The gene discussed is CRP; the disease is bacterial infectious disease.