PNPLA3 and Cirrhosis: The multivariable Cox regression model, adjusted for sex and BMI, shown that the development of cirrhosis was significantly associated with age at the start of at-risk alcohol consumption (HR = 1.10, 95% CI: 1.07–1.12, p < 0.001), PNPLA3 (HR = 2.36, 95% CI: 1.44–3.87, p < 0.001), and HSD17B13 variants (HR = 0.62, 95% CI: 0.40–0.96, p = 0.03).