GCG and type 2 diabetes mellitus: To ameliorate the altered incretin effects in T2DM, glutides or the GLP-1 RAs, i.e., albiglutide (ALBI), dulaglutide (DULA), exenatide (EXE), liraglutide (LIRA), lixisenatide (LIXI) in injectable formulations, and semaglutide (SEMA) in injectable and oral formulations, are introduced as effective therapeutic approaches.