In this study, we evaluated and compared the RAS components (Ang 1–7, Ang II plasma levels, Ang 1–7/Ang II ratio) and ArA metabolites (HETEs, EETs and DHETs) between healthy controls and COVID-19 patients to determine whether the RAS axes were unbalanced in COVID-19 patients and impacted on the ArA pathway and its metabolites profiles. This evidence concerns the gene ANGPT1 and COVID-19.