Neutrophil activity may also coordinate inflammatory signaling in OB patients with severe COVID-19 as observed by the significantly higher expression of TREM-1 on HD neutrophils, in congruence with the hyperinflammatory phenotype (CD11b+CD16+CD182+TREM-1+) that was strongly and positively associated with total leukocytes in this population. Here, ITGAM is linked to COVID-19.