CD274 and obesity due to melanocortin 4 receptor deficiency: For instance, Santos e Silva et al. found 17 genes related to innate immune dysfunction in autopsy lungs of COVID-19 patients with obesity, including a higher expression of the suppressive marker programmed death ligand 1 (PD-L1, also known as CD274), antigen-presentation (MHC-class II), cytokine signaling and neutrophil migration, such as CXCR2 (CD182) and antibody-dependent effector receptors, such as the FCGR3A and FCG3B (CD16+).