Additional data from our laboratory demonstrated a significant reduction of total CD3+ lymphocytes (p = 0.02) and a higher frequency of T naïve helper expressing PD-1 (CD3+CD4+CD28+CD279+; p = 0.04) in this population of COVID-19 patients with obesity compared to N-OB group (unpublished data). Here, CD28 is linked to obesity due to melanocortin 4 receptor deficiency.