When these significant outcomes were adjusted for sex and age, only the frequency of NK cells (p-adjusted = 0.04), the MFI of CD274 on monocytes (p-adjusted = 0.03) and the MFI of TREM-1+ on HD neutrophils (p-adjusted = 0.03) remained significantly increased in OB patients with severe COVID-19. The gene discussed is CD274; the disease is COVID-19.