Based on a large genome-wide association study, PNPLA3, transmembrane 6 superfamily member 2 (TM6SF2), and membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) were determined to be associated with ALD progression presumably via modulating lipid metabolism and/or HCC risk, for which the exact mechanisms have remained unclear [57]. The gene discussed is TM6SF2; the disease is hepatocellular carcinoma.