PCa-associated tumour intrinsic factors such as decreased MHC class I expression, low tumour-associated antigen expression, loss of tumour suppressor protein PTEN, dysfunctional signalling of type I interferons, and mutations in the DNA damage repair genes BRCA1 and BRCA2 contribute towards the evolution of immunologically cold PCa TME [155]. Here, BRCA1 is linked to posterior cortical atrophy.