As the protein expression of GluA3 tends to decrease with age in both postmortem samples of AD patients and healthy controls (Figure 4e), our studies are potentially challenged by the heterogeneity in the age of the hippocampal AD samples being analyzed (for details see Supplementary Table S1) and the highly dynamic nature of synaptic AMPAR trafficking [46]. The gene discussed is GRIA3; the disease is Alzheimer disease.