In addition, mouse lines that express both tau and Aβ pathologies, such as 3xTg AD mice, represent a powerful tool to study whether the postsynaptic AKAP5 expression is affected by Aβ and/or tau, given that Aβ deposition (3–4 months) chronologically precedes the tau tangles (7 months) [56]. This evidence concerns the gene AKAP5 and Alzheimer disease.