MAPT and supranuclear palsy, progressive, 1: The association between cholinergic disruption and tau pathology may have implications for other tauopathies that affect motor systems, including Progressive Supranuclear Palsy (PSP), a neurodegenerative movement disorder characterized, neuropathologically, by aggregated tau pathology in the globus pallidus, a region within the striatum [118], and by the loss of cholinergic projection neurons in the acoustic startle-mediating PPT [119].