As tau pathology in the brain has been demonstrated to have transdiagnostic relevance to psychosis, including in AD, [9], psychosis secondary to traumatic brain injury [50], and late-life psychotic depression [51], we have investigated the ability of tau to disrupt behaviors in mice, with relevance to human psychosis, that can be modeled in rodents—spontaneous locomotion, startle response, and sensorimotor gating [12]. Here, MAPT is linked to major depressive disorder.