While the tauopathy of AD has been well characterized, as there are no known autosomal dominant mutations in the microtubule-associated protein tau (MAPT) gene that are associated with familial AD, transgenic models that express mutant forms of human tau, associated with frontotemporal dementia [52], have been employed to study outcomes with relevance to the disease [53]. This evidence concerns the gene MAPT and Alzheimer disease.