MAPT and psychotic disorder: While the use of amphetamine [122] to induce diffuse increases in dopamine [88] has remained predominant in preclinical models of psychosis employing locomotion and sensorimotor gating [123,124,125], the use of muscarinic antagonism, as a modeling strategy in tau models, is supported only by the experiments in the current report focused on relevant locomotor (rather than sensorimotor gating) outcomes [12].