LRRK2 and Parkinson disease: To date, more than 50 mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified, however, G2019S was found to be the most prevalent mutation associated with PD with a frequency of 1% in sporadic and 4% in familial PD patients worldwide [10]), with higher incidence rates among Ashkenazi Jews and north African Berber Arabs (~20–40%) [11].