Considering the lack of consistency in the currently available findings on the association between NPS and AD biomarkers [20] in people with MCI and NPS, who may have the greatest risk of progression to dementia, the aim of this study was to qualify the association between the most commonly used AD biomarkers (i.e., Aβ and p-tau and hippocampal neurodegeneration) and NPS severity levels in a sample of people with MCI. This evidence concerns the gene MAPT and Alzheimer disease.