According to the results (Figure 1), CXCR members were commonly expressed in different pan-cancers; CXCR2 (Tumor: 1.13 ± 1.08; Normal: 0.10 ± 0.07; p = 4.8 × 104), CXCR4 (Tumor: 64.05 ± 43.39; Normal: 7.97 ± 2.34; p = 2.4 × 104), CXCR5 (Tumor: 2.73 ± 1.49; Normal: 1.35 ± 0.76; p = 0.02), and CXCR6 (Tumor: 0.71 ± 0.87; Normal: 0.12 ± 0.05; p = 0.02) expressions were significantly upregulated in GBM. This evidence concerns the gene CXCR2 and glioblastoma.