In this study, Cox survival regression analysis was used to determine the effect of CXCR4 on the prognosis of GBM patients, and we included age, sex, IDH1 mutation status, GBM subtype, chemotherapy status, radiotherapy status, and CXCR4 mRNA expression in the TCGA database for analysis. The gene discussed is CXCR4; the disease is glioblastoma.