This compound also significantly modulated the expression of NF-kB-associated genes and proteins and inhibited PD-L1 gene expression, demonstrating that HPT can reduce inflammation, which is also a critical factor in the progression of A.D. Moreover, aging also plays an important role in neurodegenerative diseases, specifically A.D. As one ages, the levels of antioxidants decrease, resulting in the overproduction of ROS. This evidence concerns the gene CD274 and neurodegenerative disease.