Xue Zhang revealed that the inhibition of P2X4R expression resulted in promoted autophagy, which elevated the Beclin-1 level and the ratio of LC3B-II/LC3B-I and decreased p62 expression in 6-hydroxydopamine (6-OHDA)-induced PD to alleviate PD progression [27]. The gene discussed is BECN1; the disease is Parkinson disease.