Considering the previous studies, we put forward the hypothesis that RES promotes autophagy by regulating the SNHG1/miR-128-3p/SNCA axis, preventing neuronal injury in PD, which suggests that RES might play a preventive effect on PD progression and the SNHG1/miR-128-3p/SNCA axis might be a novel axis for PD treatment. This evidence concerns the gene SNCA and Parkinson disease.