Moreover, SNHG1, miR-128-3p and SNCA were also indicated by our study to be regulated by RES, and it was further found that RES could promote autophagy by regulating the SNHG1/miR-128-3p/SNCA regulatory axis, thereby protecting human neuroblastoma cells and preventing PD. This evidence concerns the gene SNHG1 and Parkinson disease.