In search of BTKi resistance-associated gene expression signatures, Zhang et al. performed RNA sequencing of ibrutinib-sensitive and resistant MCL tumors and identified the differentially expressed genes involved in glycolysis, glutaminolysis, and mitochondrial biogenesis related to metabolic reprogramming of oxidative phosphorylation (OXPHOS)[34]. The gene discussed is IBTK; the disease is mantle cell lymphoma.